Journal: Acta Physiologica (Oxford, England)
Article Title: Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan
doi: 10.1111/apha.70189
Figure Lengend Snippet: Treatment with senolytic ABT‐263 alleviates Tac‐induced microvascular injury and hypertension. Representative images of H&E, Masson and EVG staining in mesenteric arteries (A, n = 6) and H&E, PAS and Masson in Af‐Art (C, n = 6). Media thickness, media‐to‐lumen ratio, collagen, elastin in mesenteric arteries (B, n = 6) and Af‐Art (D, n = 6) were calculated. Concentration response curves to Ang II and ACh in mesenteric arteries from mice treated with ABT‐263 (ABT) or Tac + ABT (E,F, n = 6). Concentration response curves to Ang II and ACh in renal Af‐Art from mice treated with ABT or Tac + ABT (G,H, n = 6). Systolic blood pressure, diastolic blood pressure, mean blood pressure and heart rate in ABT or Tac + ABT mice were detected by tail‐cuff system (I–L, n = 6). (* p < 0.05 versus Control). Statistical differences were calculated by one‐way ANOVA followed by Tukey's post hoc test (B,D), and two‐way ANOVA followed by Dunnett's post hoc test (E–L).
Article Snippet: Blood pressure in conscious mice was measured using non‐invasive tail‐cuff plethysmography (BP‐2000; Visitech Systems, NC, USA), as previously described [ ].
Techniques: Staining, Concentration Assay, Control